A major scientific report issued by 13 federal agencies on Friday presents the starkest warnings to date of the consequences of climate change for the United States, predicting that if significant steps are not taken to rein in global warming, the damage will knock as much as 10% off the size of the American economy by the end of the century.

The 1,656-page assessment lays out the devastating effects of a changing climate on the economy, health and environment, crop failures and crumbling infrastructure.